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Antipsychotic safety

Blood-sugar checks on antipsychotics

If you take an antipsychotic, your blood sugar (an HbA1c test) should be checked before you start and at least once a year.

69% of the time this step is missed
11% missed at the best-performing clinics
5.1x higher risk of harm when missed
Safety first: Never stop an antipsychotic on your own - ask about monitoring, not stopping.

The silent should: If you take an antipsychotic, your blood sugar (an HbA1c test) should be checked before you start and at least once a year.

In our analysis of de-identified U.S. psychiatric records, this step was missing 69% of the time it should have happened.

It is fixable: the best-performing clinics miss it only 11% of the time — a 58-point gap that is about the system, not the patient.

Why it matters: Incident T2DM in forward 12mo: 5.06x (95% CI 4.74-5.40) for A1c>=6.5 without metformin vs A1c<5.7 among monitored AP users.

Not everyone is missed equally: For Native American patients this step is missed 84% of the time, versus 46% for White patients.

This page is information to help you ask questions — it is not medical advice, and you should never start, stop, or change a medication on your own. Bring these questions to your clinician.

Questions for your doctor the next time you see them

Copy a line and ask it — these are questions, never instructions to change treatment.

  • I take an antipsychotic - when was my last blood-sugar (HbA1c) test?
  • Can we check my blood sugar and keep an eye on it over time?

The evidence

New type 2 diabetes in the following 12 months: 5.06x (95% confidence interval 4.74-5.40) for A1c>=6.5 without metformin vs A1c<5.7 among monitored antipsychotic users.

This page is informational and not medical advice. It describes care patterns across a population, not your situation. Bring these questions to a clinician who knows you.

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